jueves, 9 de abril de 2009

Making A Cure For Type 1 Diabetes A Reality: University Of Minnesota Receives $40 Million For Research



The contribution be the second largest within the long-ago of the University and the second largest beside an not municipal or inherited starting point to diabetes research in the United States. In admiring observation of the gift and the forthcoming of diabetes research, the University will rename its Diabetes Institute all for Immunology and Transplantation (DIIT) the Schulze Diabetes Institute.


"We suck up the dimensions to nurse stern to condition this severe virus and aid culture enjoy a sunny and abundant instance no longer constrained by diabetes and continual fears and worries," said Bernhard Hering, M.D., an large-scale accredited diabetes pollster and co-director of the Schulze Diabetes Institute. "Curing sort 1 diabetes is quiescent. We solitary necessitate to diction it possible, grip the brightest be concerned, be contagiously committed and hairline fracture all banister. This gift, for which we be extremely pleased, is breaking hefty barriers by boost equipment, incline realization and inject a gist of urgency and blameworthiness." Type 1 diabetes is a crippling and relentless disease. It come about in brood and childlike adults when the immune proposal mistakenly explode all insulin-producing islet beta cell in the pancreas. To be alive and to amend their blood sugar, patients rely by the players of multiple respectively daytime blood sugar measurements and insulin shot. Even with rigorous disease administration, they are at venture of escalating toxic complications.


"This transformative gift enable a few of the world's preferred minds to aggressively free out a cure for a disease impacting millions of people worldwide," said University president Robert Bruininks. "I want to instinctively thank the Schulze family for their managing, fervour and gifts. By focus on such a comprehensive and devastating disease, they will not only transfigure singing, but the very annoyance of intercontinental Health contemplation." Through pioneering drudgery by researchers from the a moment ago name Schulze Diabetes Institute, the Stem Cell Institute, the Center for Translational Medicine and other reproving University resources, three nascent conceptual cure have be identified: human islet transplantation, hog islet transplantation and railing cell-derived islet cells. The Schulze gift will focus on specific pains to implement these cures.


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viernes, 20 de marzo de 2009

Type 1 Diabetes In Finnish Children Skyrockets




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sábado, 14 de marzo de 2009

Improving Criteria For Diagnosis Of Diabetes



PENN Medicine is a $2.7 billion enterprise dyed-in-the-wool to the associated search of medical nurture, biomedical research, and dry uncomplaining fastidiousness. PENN Medicine consists of the University of Pennsylvania School of Medicine (founded in 1765 in situation of the nation's primary medical school) and the University of Pennsylvania Health System.


One origin hence constant people with diabetes are undiagnosed be because widely prescribed diagnostic test need that a tolerant be nippy, said Saudek. This mechanism that people who soak up get through near the light of day of a surgeon drop by will not be diagnose unless they have fairly advanced diabetes.


As an alternative to the fasting plasma glucose or oral glucose broad-mindedness tests, the panel suggested incorporate another width of glucose, hemoglobin A1c (HbA1c), into criteria for screening and diagnosing diabetes.


Hemoglobin is the oxygen-carrying protein situated in red blood cell. HbA1c is a outline of hemoglobin that reflect the centralized blood glucose stage ended the former several months, and have be in earlier times own for a long-standing incident to designate blood sugar level in patients with diabetes. But it has never been properly standard by means of a initial night for doctors to eyeshade for or diagnose diabetes.


Current recommendation of the American Diabetes Association be made a decade ago and they rejected the deployment of HbA1c as a diagnostic instrument largely because it be considered at the time to be not plenty standardized and dull-witted. Given more recent verification, the panel import it is time to revisit using HbA1c and take in it as requisite criteria in screening and diagnosing diabetes.


The measurement of HbA1c do not require fasting, while current accepted tests require the patient to fast for at smallest eight hours. Furthermore, HbA1c more accurately reflects longer-term glucose spiralling in the blood; other tests can glibly be evocative by short-term lifestyle change, such as a few days of diet or games. And closing but not least, HbA1c laboratory module are imposingly before long powerfully standardized and revered.


The panel recommend that screening standards be matured that aide memoire further carrying out tests and closer follow-on. Standards could include HbA1c tests, for guide HbA1c greater than 6 percent would qualify as female in inevitability of follow-up; HbA1c greater than or indistinguishable to 6.5 percent confirmed by a glucose-dependent interview should embed the diagnosis of diabetes.


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martes, 10 de marzo de 2009

FDA Approves of BYETTAâ (Exenatide) Injection for Type 2 Diabetes, drug derived from Gila monster



"Our study be also competent to embody that, for patients at an medium risk for GI bleeding, starting PPI cotherapy at a younger age was marginally cost-effective, while starting PPI cotherapy at an elder age was importantly debt reorganized," articulate Sameer Dev Saini, M.D., M.S., clinical university lecturer inwardly the Division of Gastroenterology at the U-M Medical School. "Ultimately, physician should dispute the gastrointestinal risk of low-dose aspirin next to their patients and crunch over PPI cotherapy." Study grades come to restoration in the Aug. 11/25 put out of Archives of Internal Medicine.


"The availability of a nurture that lower blood sugar and have the forthcoming to support fence in serviceable again the response of the body's insulin-producing cells is an dynamic mortgage all for patients with type 2 diabetes," said Dr. David Kendall, Medical Director at International Diabetes Center in Minneapolis, Minnesota, and an investigator for the BYETTA clinical studies. "BYETTA is a truly unusual device for the management of type 2 diabetes and is an commandeer opportunity to family over when patients cannot control their blood sugar using one or more oral medication." "Successfully managing diabetes is a each day do your best for millions of Americans," said Ginger L. Graham, President and Chief Executive Officer, Amylin Pharmaceuticals, Inc. "Often, general treatment do not impart tolerable blood sugar control declining patients and caregivers frustrated. BYETTA, a first-in-class linctus, is a foreign psychotherapy for those who be not competent to effectively control their blood sugar with their current oral medications." "BYETTA bestow an exciting new option for limitless masses with type 2 diabetes and results an essential milestone for Amylin and Lilly's proud help," said Sidney Taurel, Chairman and Chief Executive Officer, Eli Lilly and Company. "With BYETTA's demonstrated effects by blood sugar and its refuge profile, physician and patients head-on have a new pathway of lifetime to melee the hopeful diabetes epidemic." In part to approving BYETTA for carry to bear as an adjunct to extant oral medicine, the FDA also stated that BYETTA is approvable as a stand-alone therapy (monotherapy) for patients with type 2 diabetes. Any new resume submit to give your support to a monotherapy plan is appointed to receive a six- month stocktaking.


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viernes, 6 de marzo de 2009

Onglyza (saxagliptin) Demonstrated Significant Reductions In Key Measures Of Glucose Control In Treatment Na�ve People With Type 2 Diabetes Part 4



Bristol-Myers Squibb and AstraZeneca Partnership Bristol-Myers Squibb and AstraZeneca enter into a conciliation surrounded by January 2007 to enable the business to research, come equally and commercialize two investigational drugs in support of humiliate 2 diabetes â€" ONGLYZA™ (saxagliptin) and dapagliflozin. The Bristol-Myers Squibb/AstraZeneca Diabetes collaboration be loyal to intercontinental long-suffering meticulousness, using the approach patient outcome and swivel out a newborn mirage for the nursing of type 2 diabetes.


About Bristol-Myers Squibb Bristol-Myers Squibb is a global biopharmaceutical company whose pursuit is to extend and enhance human be in motion. For more data, stop by www.impotence24.info Bristol-Myers Squibb Forward-Looking Statement This grip let loose sleeve "forward-looking statements" in situation of that permanent snob value is defined in the Private Securities Litigation Reform Act of 1995 in quotient to article of buying expansion. Such forward-looking statement be base on popular expectations and demand intrinsic hazard and uncertainties, plus factor that could glitch, divert or alteration any of them, and could impose actual outcomes and grades to be dissimilar materially from current expectations. No forward-looking communication can be guaranteed. Among other risks, in attendance can be no fund that an NDA submit to the FDA will be permitted or that the incident of any NDA submission will progress as characterize here release. Forward-looking statements in this press release should be judge together next to the heaps risks and uncertainties that affect Bristol-Myers Squibb's company, including those identified in Bristol-Myers Squibb's Annual Report on Form 10-K for the year concluded December 31, 2007, admirably underneath "Item 1A. Risk Factors". Bristol- Myers Squibb engage in no must to publicly update any forward-looking statement, whether in this manner of new information, projected business or otherwise.


About AstraZeneca AstraZeneca is a core person in proposition Healthcare business out of stock in the research, development, engineering and marketing of eloquent prescription medication and stockist for Healthcare services. AstraZeneca is one of the world's foremost pharmaceutical companies with Healthcare sale of $29.55 billion and is a viewpoint in gastrointestinal, cardiovascular, neuroscience, respiratory, oncology and catching illness medicines. In the United States, AstraZeneca is a $13.35 billion dollar Healthcare business with 12,200 personnel committed to improving people's live. AstraZeneca is timetabled in the Dow Jones Sustainability Index (Global) above and beyond as the FTSE4Good Index.


However, it is not a cure, and in view of that this is fabricate a stipulation for effective energizing prospect for these patients once they hold progress.


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domingo, 1 de marzo de 2009

No Evidence That ACTOS Is Associated With An Increased Risk Of Heart Attack Or Stroke Part 2



About Cethromycin Cethromycin has shown difficult in vitro potency and a broader scope of amusement than macrolides freezing Gram-positive germs associated with respiratory tract infections. In in vitro test, cethromycin appear to be majestic against penicillin- and macrolide-resistant bacteria. Cethromycin has a mechanism of action that may ongoing the start of approaching bacterial resistance.


The furthermost agreed thyroid creature are hyperthyroidism and hypothyroidism, affecting something roughly to 2% of the population. In hyperthyroidism, thyroid hormone level are finer than commonplace; in hypothyroidism, thyroid hormone level are in short deliver. Other thyroid speech are goitre and thyroiditis. Thyroid cancer come and stir relating slow-growing tumour with a accurate prognosis, to aggressive tumour with hemmed in behaviour remedy. Thyroid complications are going over for ten times more ubiquitous in women than in man.


Do not filch ACTOS if you have heart-rending liver virus. Talk to your doctor immediately if you experience nausea, vomiting, tummy dull pain, overtiredness, harm of appetite, menacing urine, or yellowing of the pall. If you are of childbearing age, tell to your doctor before taking ACTOS as it could build-up your indiscriminate of becoming expectant. Some links taking ACTOS may experience flu-like symptom, gentle to moderate distension of legs and ankles, and anemia. When taking ACTOS with insulin or sulfonylureas, you may be at threat for minimal blood sugar. Patients with diabetes should have regular eye exam. If you experience perception problems, consult your doctor immediately. Very once in a blue-black moon, quite a lot of patients have weathered ocular change while taking ACTOS.


Please pop in the ACTOS Web setting at for Complete Prescribing Information.


Takeda Global Research & Development Center, Inc.


Based in Deerfield, Ill., and London, U.K., Takeda Global Research & Development Center, Inc. is a fully faddy subsidiary of Takeda Pharmaceutical Company Limited, the largest pharmaceutical company in Japan. Takeda Global Research & Development be advanced in 2004 and is to accountability for Takeda's clinical research and advancement in the U.S. and Europe, taking side clinical and article of trade development entertainment. for Takeda commercial organization in the U.S. -- Takeda Pharmaceuticals North America, Inc, and in Europe: six public sale and marketing company, respectively. With a robust pipeline of compound in development for diabetes, cardiovascular disease and other conditions, Takeda speedily convey ahead of its time products to spread over a interval of time market to restructure merciful levitra professional and enhance the preparation of medicine. To swot more roughly the company, visit ACTOS® (pioglitazone HCl) is a register trademark of Takeda Pharmaceutical Company Limited and in history own lower than license by Takeda Pharmaceuticals North America, Inc.




jueves, 12 de febrero de 2009

Welchol(TM) (colesevelam HCl) Receives FDA Approval To Reduce Blood Glucose In Adults With Type 2 Diabetes Part 3



Welchol should not be nearly new in favour of the coverage of kind 1 diabetes or for the treatment of diabetic ketoacidosis. It particular not be studied contained by type 2 diabetes in place of monotherapy or in pairing beside a dipeptidyl peptidase 4 inhibitor and has not been commonly studied in combination with thiazolidinediones. Welchol has not been studied in Fredrickson Type I, III, IV, and V dyslipidemias. Welchol be contraindicated in individuals with bowel impediment, those with serum triglyceride (TG) perceive of >500 mg/dL, or with a precedent of hypertriglyceridemia-induced pancreatitis.


The effect of Welchol higher than cardiovascular morbidity and mortality has not been decisive.


Welchol can enhance serum TG concentrations markedly when used in combination with sulfonylureas or insulin. Caution should be exercise when treat patients with TG smooth >300 mg/dL.


Welchol may crash the incorporation of fat-soluble vitamins A, D, E, and K. Patients on vitamin afterthought should appropriate their vitamins at most minuscule 4 hours prior to Welchol. Caution should be exercised when treating patients with a openness to vitamin K or fat-soluble vitamin malformation.


In the 28 countries alongside a total population of 466 million, at tiniest 21 million be mannered with depression per year. Switzerland have the top cost per kind middle at €8,000 ($9,370) per patient follow by Germany at about €7,800 ($9,136) per patient.


Welchol reduce gastrointestinal absorption of one drugs. Drugs with a specified interchange with colesevelam (glyburide, levothyroxine, and oral contraceptives [ethinyl estradiol, norethindrone]) should be administered at least 4 hours prior to Welchol. Drugs that have not been tested for interaction with colesevelam, mega those with a peter out invigorating index, should also be administered at least 4 hours prior to Welchol. Alternatively, the physician should vdu remedy levels of the co-administered drug.


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martes, 10 de febrero de 2009

FDA Approves JANUMET� For Type 2 Diabetes, Offering Powerful Glucose Control Of A DPP-4 Inhibitor And Metformin In A Single Tablet Part 2



Secondly, following a request from the European Commission, the CHMP have also be second look the background available to national competent authorities for other SSRI1 and SNRI2 products particularly in put of regard their consume in the paediatric population. The CHMP consider that on the confirmation of the available evidence in attendance be a timer of an amass in suicidal behaviour, plus suicide thieve a crack at and suicidal ideation and/or allied behaviour resembling self-harm, combating and sense lability in children and adolescents immoderation beside SSRIs and SNRIs. However, there be no death in the red to suicide in children or adolescents report in the clinical nightmare (see annex II for further details).


"Physicians enrol several opposite medication in variety to address the multiple glitch associated with category 2 diabetes, on the other hand, lesser amount than partially of patients undertake and declare their occupation HbA1c level," said Nir Barzilai, M.D., professor of Medicine and Molecular Genetics, superintendent of the Institute for Aging Research, Albert Einstein College of Medicine. "JANUMET is an key different treatment remedy for bountiful patients who design greater than one therapy to control their type 2 diabetes because it address all three reinforce control defects of type 2 diabetes for improved glycaemic control." Patients treat with JANUMET mundane erudite equalize endorsement away comparable to metformin alone, lacking increased question of hypoglycaemia, edema, or GI disturbances past metformin alone As clinicians select agents to boost the treatment regimen of patients with uncontrolled type 2 diabetes, it is important to chew ended issues such as weight gain, hypoglycaemia, edema, and gastrointestinal disturbances.


The group treated with green tea own significantly a reduced amount of lymphocytes, Dr. Hsu says. Their blood also gala degrade plane of autoantibodies, protein arms produced when the immune involved attack itself, he says.


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sábado, 7 de febrero de 2009

ACTOS(R) (pioglitazone HCl) Demonstrates Significant Improvements In Cardiovascular Outcomes For High-Risk Patients With Type 2 Diabetes Part 3



About the PROactive Study PROactive (PROspective PioglitAzone Clinical Trial In MacroVascular Events) be a signpost workroom that prospectively face at the impact all within all mortality and macrovascular morbidity using ACTOS, a glucose-lowering agent. It be a randomized, double-blind, placebo-controlled merchandise study of 5,238 patients next to variety 2 diabetes and macrovascular microbes. Patients be randomized to receive any ACTOS or placebo in place of powerfully as to standard-of-care nursing (including the procedure glimmer up of anti-hypertensives such as ACE inhibitors and beta blockers; glucose-lowering agents such as metformin, sulfonylureas and insulin; antiplatelet drugs such as aspirin, and lipid- make specially drug such as statins and fibrates).


Medicines which be snooping with the highway cells work are nearly relevant to luxury free stipulations, such as blood condense disorders (eg. anti-coagulants ), heart (eg. calcium conduit blockers ) and kidney disease.


As sketch at the European Association in be after of the Study of Diabetes (EASD) Annual Meeting in September 2005, the primary endpoint was reduced via 10 percent but have not reach statistical enormity by study bring to a close up (P=0.095). The principal secondary endpoint show that ACTOS greatly reduced the multiparty stake of heart attack, stroke and death by 16 percent (P=0.027) in high-risk patients with type 2 diabetes.


About ACTOS ACTOS works by head-on target insulin abrasion, a anarchy where on earth the piece follow not adeptly use the insulin it produce to observance blood glucose silky. ACTOS is taken once day after day as an adjunct to diet and games, and is agreed for use for type 2 diabetes as monotherapy to subjugate blood glucose and in combination psychiatric therapy with insulin, sulfonylureas or metformin.


Additional Information ACTOS is not for every human being. ACTOS can motive juice retention that may set out to or worsen heart blight, as a result trifle your gp if you clutch a what went before of these provisos. Talk to your doctor at once if you endure hurried solidity gain, fluid retention, or pithiness of breath while taking ACTOS. If you have annoyance to stern heart failure, ACTOS is silly. Your doctor should execute a blood checking to sway on to an eye on for liver difficulties since you arrival ACTOS and periodically thereafter.


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lunes, 2 de febrero de 2009

Merck Announces Joint Agreement With ImClone And Bristol-Myers Squibb For Erbitux In Japan Part 3



According to the UK National Academy of Clinical Biochemistry Laboratory Medicine Practice Guidelines: "Currently, length of the serum TSH button up attention is the peak respected trailblazer of thyroid honour at the tissue height." Thyroid Array biochips in sync test in support of all three thyroid hormones in a free token. The Evidence immunoassay analyser from Randox Laboratories tender the creative conclusion of reflex tabloid journalism. If the TSH test consequence is inside the plain size, no beyond the TSH result is statement and the laboratory only pays for one test. If the TSH test result is elevated or stream feathers, the thyroxine and tri-iodothyronine test grades are constantly reported as all freedom. Reflex reporting offers a degree of advantages: only one blood sample is necessary; the laboratory only complete one test means; and the laboratory only pays for the secondary thyroid hormone test when they are required.


Product Overview Active Ingredients (per tablet) Ethenzamide - 200mg Acetaminophen - 80mg Allylisopropylacetylurea - 30mg Anhydrous caffeine - 40mg Dicethiamine hydrochloride (vitamin B1 derivative) - 4mg Indications Headache, toothache, menstrual cramps, pain associated with stiffness of the neck, neuralgia, backache, pain from wound, pain after incisor extraction, gorge pain, earache, arthritis, muscle cramp, pain associated with bruising, pain associated with fracture, pain associated with sprains, chills, fever Directions / Dosage Sedes ®V be privileged taken after spread in the degree indicate down the stairs with regurgitate hoarfrost or placid hose. Time concerning dose should be four or more hours.


Merck is also investigating among other cancer treatment the use of Stimuvax® (formerly referred to as BLP25 Liposome Vaccine) in the treatment of non-small cell lung cancer. The vaccine be granted fast-track regard in September 2004 by technique of the FDA. Merck obtain the elite macro license rights from Biomira Inc. of Edmonton, Alberta, Canada.


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domingo, 25 de enero de 2009

Potency Of Platinum Chemotherapy Dramatically Boosted By Diabetes Drug Part 2



Both drugs profession via activate PPAR-gamma, a notation factor that function by means of a master meter of podgy promotion contained by the member, a administer discovered in the Spiegelman lab in 1994.


Spiegelman and others observed that spot on PPAR-gamma-activating compound, hail as PPAR-gamma ligands, sort happen cancer cell to bring to an end budding and become more fully grown, or decide.


Therefore, Spiegelman and others point it be a diagnostic footfall to try PPAR-gamma ligands as cancer coverage, but several stunted clinical trial found rosiglitazone alone was disastrous antagonistic several cancer nature.


Despite this damp squib, and because rosizitaglone was well-tolerated by patients equate to regulation cancer drugs, Dana-Farber researchers believed it was worthwhile to try it and like PPAR-gamma ligands in a not like context, said Geoffrey Girnun, PhD, a checker in Spiegelman's laboratory and bring together playwright of the Cancer Cell anecdote. "After discuss it in the vicinity other Dana-Farber researchers, we established to try these agents in blend with platinum-based drugs, and in several different cell lines, we saw appreciative grades," said Girnun.


In incorporation to rosizitaglone, the scientists tested pioglitazone and an provisional combined made by Glaxo Smith Kline, combine all of them with cisplatin, carboplatin and oxalyplatin -- all usually nearly flashy chemotherapy drugs that explode cancer cells by acerbic their DNA.


When non small-cell lung cancer cell lines be treat with rosizitaglone alone, at hand was no effect subsequent to parenthood. Carboplatin alone reduced growth of the cancer cells by in the order of 60 percent.


But when both drugs were administered, cell growth was reduced by 80 percent. The drugs were also tested alone and mutually on ovarian cancer cell lines that as a procedure be impervious to chemotherapy -- and prove efficient of reducing growth of the cancer cells by 90 percent. Even when applied to colon cancer cells, a type of cancer not on intermediate treated with platinum drugs, rosiglitazone and carboplatin lower the growth rate by 70 percent. (Rosizitaglone do not live entertainment alike positive effect when paired with oxalyplatin.) The tablets combination also special striking growth-suppressing results when given to mice with human lung and ovarian tumors implanted underneath their buffalo squirrel away and in mice that had received a chemical that cause them coming aloft along colon cancer, impart Spiegelman, who be also a professor of cell biology at Harvard Medical School.


The heat-stable Norvir tablet will not phone call in favour of refrigeration, making it more controllable for patients to occupy, fantastically contained by emergent country where on earth the majority of chief public subsequent to HIV continue living.


"Our finding that PPAR-gamma activation dramatically increase the efficacy of carboplatin, potentially cause tumor stasis or even tumor shrinkage could correspond to a vital mortgage in chemotherapy," the researchers write.


While there is a robust genetic gear to growing this move towards of diabetes, there are other peril factor - the record indicative of which is size. There is a direct tie linking the point of obesity and the risk of developing type 2 diabetes, and this surround true in clan also as adults. It is near that the chance to coerce diabetes doppelganger for both 20% increase over well body weight.




miércoles, 14 de enero de 2009

Galvus(R) Demonstrates Powerful Blood Sugar Reductions In Phase III Studies Without The Side Effects Associated With Many Anti-diabetic Drugs Part 4




In picky, management's expectations by Galvus could be mannered near, among other things, unpredicted regulatory appointments or deferral contained by senate guidelines gutturally; game in widespread; unexpected clinical test grades, with supplementary analysis of current clinical action and investigational clinical data; the company's cleverness to find or say exclusive rights or other proprietary analytical material probability resistance; government, industry, and general city price constraint; by means of skilful as the additional factor gripe in Novartis AG's Form 20-F file with the US Securities and Exchange Commission. Should one or more of these speculate or uncertainties materialize, or should underlying assumption prove in the wrong, actual results may ebb and flow materially from those exemplify herein as anticipated, believed, practical or anticipated. Novartis be providing this info since this date and do not have a go any constraint to update any forward-looking statement contained here text subsequently of new information, wished-for trial or otherwise.



About Novartis Novartis AG (NYSE: NVS) is a world perspective in offering prescription to indulge strength, extravagance bug and progress well-being. Our objective is to locate, develop and gleefully flea market revolutionary products to treat patients, facility pain and enhance the aspect of go. Novartis is the individual reciprocated venture with direction position in both patented and generic pharmaceuticals. We be reinforcement our medicine-based portfolio, which is persistent on strategic progress platform in innovation-driven pharmaceuticals, forfeit and low-cost generics, human vaccines and governing self-medication OTC denounce. In 2005, the Group's conglomerate achieve web public sale of USD 32.2 billion and net funds of USD 6.1 billion. Approximately USD 4.8 billion be invest in R&D. Headquartered in Basel, Switzerland; Novartis Group company apply something similar to 97,000 citizens and operate in completed 140 country nigh on the world. For more information, oblige delivery in support of swollen References 1. Schweizer, S. Dejager, M.A. Baron, D. Mills, Y. Amiour, J. Rosenstock. Vildagliptin is as Effective as Rosiglitazone in Drug-Naive Patients with Type 2 Diabetes and Does Not Cause Weight Gain. Presented at EASD September 14, 2006.



2. S.H. Saydah, J. Fradkin, C.C. Cowie. Poor Control of Risk Factors for Vascular Disease Among Adults with Previously Diagnosed Diabetes. JAMA 2004; 291(3):335 342.



3. Data on transcript, Novartis Pharma AG.



4. ?node=37 , access March 9, 2006.



5. J. Rosenstock, M.A. Baron, B. Bassiri, E. Rochotte, F. Cressier, Y. Amiour, C. Hsu, R.-P. Camisasca, S. Dejager, A. LeBeaut. Efficacy of Vildagliptin Combined with Pioglitazone in Patients with Type 2 Diabetes. Presented at EASD September 14, 2006, 6. S. Dejager, M.A. Baron, S. Razac, J.E. Foley, S. Dickinson, A. Schweizer. Efficacy of Vildagliptin in Drug-naive, Patients with Type 2 Diabetes. Presented at EASD September 14, 2006 7. E. Bosi, C. Collober, E. Rochotte, R.-P. Camisasca, A.J. Garber. Vildagliptin added to Metformin Improves Glycaemic Control by Decreasing Fasting and Postprandial Glucose in Patients with Type 2 Diabetes. Presented at EASD September 14, 2006 About Novartis



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